Understanding how proteins interact with carbohydrates to influence cell communication and disease.
Official title: A covalent strategy to profile the reader proteins of glycosylation
Funded at Georgia State University · NIH-11020302 · Data updated 2026-11-12
This study is looking at how certain proteins and sugars in our bodies work together, which is important for understanding diseases like cancer, and it hopes to find new ways to help patients by learning more about these interactions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 1R35GM157040-01 |
| Project ID | NIH-11020302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with conditions related to cancer metastasis or other diseases where glycosylation plays a significant role.
✕Less likely to help
Patients with conditions unrelated to glycosylation or those not experiencing disease progression influenced by protein-carbohydrate interactions may not benefit from this research.
What this research studies
This research investigates the interactions between proteins and carbohydrates, specifically focusing on glycan-binding proteins that play a crucial role in cell communication and disease processes such as cancer metastasis. By developing a new platform to map these interactions, the research aims to uncover how these proteins regulate important biological functions and could lead to new therapeutic strategies. The approach combines organic synthesis, molecular biology, and protein science to create tools that can effectively study these complex interactions. Patients may benefit from insights gained into how glycosylation affects disease progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic interventions that improve treatment outcomes for patients with diseases influenced by glycosylation.
How similar studies have gone: While the study of protein-carbohydrate interactions is less explored compared to protein-protein interactions, there is growing interest and preliminary success in related research areas, indicating potential for impactful findings.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Yu, Bingchen — Georgia State University
- Study coordinator: Yu, Bingchen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.