Understanding how proteins interact to improve treatment for pulmonary arterial hypertension
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension
This study is looking at how different proteins interact in people with pulmonary arterial hypertension (PAH) to find new ways to tailor treatments just for you, helping to better understand your condition and improve your care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11145599 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between proteins in patients with pulmonary arterial hypertension (PAH), a serious condition that affects blood vessels in the lungs and can lead to heart failure. By analyzing the unique biological profiles of individuals with PAH, the study aims to identify specific features that contribute to the disease's progression and response to treatments. The approach utilizes advanced network medicine techniques to uncover important signaling pathways that could serve as new targets for therapy, moving beyond traditional methods that may overlook critical biological functions. Patients may benefit from more personalized treatment strategies based on their unique disease characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who may benefit from personalized treatment approaches.
Not a fit: Patients with other forms of pulmonary hypertension or those without a confirmed diagnosis of pulmonary arterial hypertension may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatment options for patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promise in using network medicine approaches to identify novel therapeutic targets in similar conditions, suggesting potential for success in this area.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Maron, Bradley — University of Maryland Baltimore
- Study coordinator: Maron, Bradley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.