Understanding how proteins interact at the cell surface in various diseases
Dissecting the Diverse Roles of Importin α at the Plasma Membrane
This study is looking at how a certain protein helps cells divide and communicate, which is important for understanding diseases like cancer and Alzheimer's, and it uses cool technology to see these processes in action.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10912558 on NIH RePORTER |
What this research studies
This research investigates the roles of a specific protein in controlling the formation of macromolecular complexes at the plasma membrane, which is crucial for cell division and signaling. By using advanced techniques like microfluidics and optogenetics, the study aims to precisely manipulate and observe these interactions in real-time. The goal is to identify new therapeutic targets for diseases such as cancer and neurodegenerative disorders, including Alzheimer's disease, by understanding how these protein interactions change in different conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or other neurodegenerative disorders.
Not a fit: Patients with non-neurological conditions or those not diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic and treatment options for patients with Alzheimer's disease and other related conditions.
How similar studies have performed: Other research has shown promise in targeting protein interactions at the cell membrane for therapeutic purposes, indicating that this approach could yield significant advancements.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Brownlee, Christopher William — State University New York Stony Brook
- Study coordinator: Brownlee, Christopher William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.