Understanding how proteins influence kidney stone formation
Official title: Protein interactions that control calcium oxalate stone formation
Funded at Medical College of Wisconsin · NIH-10943469 · Data updated 2026-11-12
This study is looking at how certain proteins help form calcium oxalate kidney stones, which many people deal with, to find better ways to prevent and treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 22, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $434,502 |
| NIH project number | 1R01DK140369-01 |
| Project ID | NIH-10943469 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have a history of calcium oxalate kidney stones or are at high risk for developing them.
✕Less likely to help
Patients who do not have a history of kidney stones or are not at risk for developing them may not benefit from this research.
What this research studies
This research investigates the role of proteins in the formation of calcium oxalate kidney stones, which affect a significant portion of the population. By examining how different proteins interact and aggregate to form these stones, the study aims to uncover the underlying mechanisms that contribute to stone development. The approach involves analyzing protein compositions and their behaviors in relation to calcium oxalate crystals, using advanced techniques like atomic force microscopy. This could lead to new insights into preventing and treating kidney stones more effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for kidney stones, reducing recurrence rates and enhancing patient quality of life.
How similar studies have gone: While there has been extensive research on kidney stones, this specific focus on protein interactions and their role in stone formation represents a novel approach that has not been extensively tested.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Wesson, Jeffrey a — Medical College of Wisconsin
- Study coordinator: Wesson, Jeffrey a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.