Understanding how proteins influence kidney stone formation
Protein interactions that control calcium oxalate stone formation
This study is looking at how certain proteins help form calcium oxalate kidney stones, which many people deal with, to find better ways to prevent and treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10943469 on NIH RePORTER |
What this research studies
This research investigates the role of proteins in the formation of calcium oxalate kidney stones, which affect a significant portion of the population. By examining how different proteins interact and aggregate to form these stones, the study aims to uncover the underlying mechanisms that contribute to stone development. The approach involves analyzing protein compositions and their behaviors in relation to calcium oxalate crystals, using advanced techniques like atomic force microscopy. This could lead to new insights into preventing and treating kidney stones more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have a history of calcium oxalate kidney stones or are at high risk for developing them.
Not a fit: Patients who do not have a history of kidney stones or are not at risk for developing them may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for kidney stones, reducing recurrence rates and enhancing patient quality of life.
How similar studies have performed: While there has been extensive research on kidney stones, this specific focus on protein interactions and their role in stone formation represents a novel approach that has not been extensively tested.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Wesson, Jeffrey a — Medical College of Wisconsin
- Study coordinator: Wesson, Jeffrey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.