Understanding how proteins in primary cilia affect kidney disease
Official title: Investigate the trafficking and function of polycystins in primary cilia and their implications for polycystic kidney disease
Funded at Mayo Clinic Rochester · NIH-11064039 · Data updated 2026-11-12
This study is looking at how certain proteins important for kidney health work in tiny structures on cells, with the hope of finding new ways to slow down the progression of autosomal dominant polycystic kidney disease (ADPKD) and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $487,539 |
| NIH project number | 5R01DK139607-02 |
| Project ID | NIH-11064039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with autosomal dominant polycystic kidney disease (ADPKD).
✕Less likely to help
Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
What this research studies
This research investigates the role of polycystins, proteins that are crucial for kidney function, in primary cilia, which are tiny hair-like structures on cells. By exploring how these proteins are trafficked and function within the cilia, the research aims to uncover mechanisms that could slow the progression of autosomal dominant polycystic kidney disease (ADPKD). The study will involve various experimental approaches to understand the regulation of these proteins and their impact on kidney health. If successful, this research could lead to new treatment strategies that improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with polycystic kidney disease, potentially delaying the need for dialysis or transplantation.
How similar studies have gone: Previous research has shown promise in understanding the role of cilia in kidney disease, making this approach a continuation of established findings.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Ling, Kun — Mayo Clinic Rochester
- Study coordinator: Ling, Kun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.