Understanding how proteins in CD8 T cells change to improve immune responses
Determination of chromatin protein dynamics in CD8 T cells
['FUNDING_R21'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10874555
This study is looking at how certain proteins in immune cells called CD8 T cells work when they fight off viruses and tumors, with the goal of finding new ways to help improve treatments for diseases related to the immune system and cancer.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10874555 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamics of chromatin proteins in CD8 T cells, which are essential for fighting viral infections and tumors. By examining how these cells respond to various stimuli, the study aims to uncover the mechanisms that regulate their differentiation and function through gene expression. Utilizing advanced techniques like CRISPR screening, the researchers hope to identify new factors that influence CD8 T cell behavior, potentially leading to improved therapies for immune-related diseases and cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with immune disorders or cancers that may benefit from enhanced CD8 T cell function.
Not a fit: Patients with conditions unrelated to immune function or those who do not have active immune disorders or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses against infections and cancer.
How similar studies have performed: Other research has shown promising results using similar approaches to manipulate immune cell functions, indicating potential for success in this area.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FENG, YONGQIANG — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: FENG, YONGQIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer