Understanding how proteins help nerve cells communicate and transport lipids
Single-molecule studies of SNARE assembly and lipid transfer
This study is looking at how certain proteins help nerve cells communicate by making tiny bubbles in the cells merge, which is important for sending messages in the brain, and the findings could help us understand and treat brain disorders related to this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11127430 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which proteins called SNAREs facilitate the fusion of synaptic vesicles in nerve cells, which is crucial for communication between neurons. By examining the assembly of these proteins and their interactions with lipid transfer proteins, the study aims to uncover the dynamics that enable the transport of lipids between membranes. The research employs advanced techniques such as fluorescence microscopy and laser tweezers to visualize and analyze these processes at the molecular level. Patients may benefit from insights gained into neurological disorders linked to synaptic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological disorders that affect synaptic transmission.
Not a fit: Patients with non-neurological conditions or those not affected by synaptic dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders related to synaptic dysfunction.
How similar studies have performed: Previous research has shown success in understanding synaptic mechanisms, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Zhang, Yongli — Yale University
- Study coordinator: Zhang, Yongli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.