Understanding how proteins help maintain our DNA
Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance
This study is looking at how certain proteins help keep our DNA safe and working properly, which is important for preventing genetic diseases, and it's for anyone interested in understanding how our bodies repair and replicate DNA.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10829867 on NIH RePORTER |
What this research studies
This research investigates the roles of DNA helicases and single-stranded DNA-binding proteins in maintaining the integrity of our genome. By studying how these proteins interact and function during DNA replication, recombination, and repair, the research aims to uncover the mechanisms behind DNA unwinding and protection. The approach involves quantitative studies of specific DNA helicases and their interactions with other proteins, which could lead to insights into genetic diseases caused by defects in these proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders related to DNA repair deficiencies.
Not a fit: Patients with conditions unrelated to DNA repair or genetic recombination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic disorders linked to DNA repair mechanisms.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Lohman, Timothy M — Washington University
- Study coordinator: Lohman, Timothy M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.