Understanding how proteins help in the formation of dental and skeletal structures
Functions of extracellular matrix proteins in dental and skeletal mineralization
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10626826
This study is looking at how certain proteins help build and heal the tissues around your teeth and bones, which is important for keeping your teeth healthy and strong, and it's being done using specially modified mice to learn more about these processes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10626826 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular matrix proteins, particularly bone sialoprotein, in the formation and regeneration of dental and skeletal tissues. It focuses on understanding how these proteins contribute to the health of the periodontal complex, which includes cementum, periodontal ligament, and alveolar bone. By studying genetically modified mice, the research aims to uncover the mechanisms behind cementum formation and the healing processes of alveolar bone, which are crucial for maintaining tooth attachment and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from periodontal diseases or conditions affecting dental and skeletal health.
Not a fit: Patients with no dental or skeletal issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for periodontal diseases, enhancing tooth retention and overall oral health.
How similar studies have performed: Previous research has shown promise in understanding the roles of extracellular matrix proteins in tissue regeneration, suggesting that this approach could yield significant insights.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOSTER, BRIAN LEE — OHIO STATE UNIVERSITY
- Study coordinator: FOSTER, BRIAN LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.