Understanding how proteins help control cell growth and development
Official title: Investigating the Regulatory Roles of Histone Chaperones in Cellular Plasticity
Funded at University of California Riverside · NIH-10895477 · Data updated 2026-11-12
This study is looking at special proteins that help organize DNA in our cells to see how they affect how cells grow and change, which could be important for understanding how our bodies adapt and develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $388,750 |
| NIH project number | 5R35GM151004-02 |
| Project ID | NIH-10895477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve abnormal cell growth or differentiation, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular reprogramming or proliferation may not benefit from this research.
What this research studies
This research investigates the role of histone chaperones, which are proteins that assist in organizing DNA and its associated proteins in cells. By studying how these chaperones influence cellular processes such as growth, multiplication, and differentiation, the research aims to uncover their impact on cellular plasticity—the ability of cells to change and adapt. The approach involves examining how these proteins interact with DNA during critical processes like replication and transcription, which are essential for cell function and development.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how to manipulate cell growth and differentiation, potentially benefiting patients with developmental disorders or diseases related to cell proliferation.
How similar studies have gone: Previous research has shown promising results in understanding the roles of histone chaperones in cellular processes, indicating that this area of study has potential for significant advancements.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Cheloufi, Sihem — University of California Riverside
- Study coordinator: Cheloufi, Sihem
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.