Understanding how proteins help cholesterol processing in the body
The structural basis for cholesterol esterification in human plasma
This study is looking at how certain proteins help an important enzyme work better to manage cholesterol in the body, which could lead to better understanding and treatment of heart health issues related to cholesterol.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10667541 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins, known as apolipoproteins, in enhancing the activity of an enzyme called lecithin:cholesterol acyl transferase (LCAT), which is crucial for cholesterol processing in the human body. The study aims to uncover the molecular mechanisms by which these proteins interact with LCAT to facilitate the conversion of cholesterol into cholesteryl esters, a form that can be transported in the bloodstream. By using advanced experimental techniques, the researchers will explore how different apolipoproteins affect LCAT's function and how disruptions in these interactions may impact cholesterol metabolism. This research could provide insights into cardiovascular health and the management of cholesterol-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with dyslipidemia or other cholesterol-related disorders.
Not a fit: Patients without any cholesterol metabolism issues or those not at risk for cardiovascular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of cardiovascular diseases related to cholesterol metabolism.
How similar studies have performed: Previous research has shown promising results in understanding the role of apolipoproteins in cholesterol metabolism, indicating that this approach has potential for success.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Davidson, W Sean — University of Cincinnati
- Study coordinator: Davidson, W Sean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.