Understanding how proteins help cells fuse their membranes
Lipid Bilayer Remodeling and Protein Intermediates During Membrane Fusion
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10869958
This study is looking at how certain proteins help cell membranes stick together, which is important for many body functions, and it aims to find out how this process works so we can better understand and treat diseases like viral infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10869958 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which proteins facilitate the fusion of cell membranes, a process crucial for various biological functions. By using advanced techniques like cryo-electron microscopy and structural mass spectrometry, the researchers aim to visualize and analyze the intermediate states of membrane fusion in real-time. This approach will help uncover how fusion proteins manipulate lipid membranes and how these processes can be affected by diseases or therapeutic interventions. The findings could lead to better understanding and treatment of viral infections and other conditions related to membrane fusion.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by viral infections, such as COVID-19 or AIDS, where membrane fusion plays a critical role in disease progression.
Not a fit: Patients with conditions unrelated to membrane fusion or those not affected by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing viral infections and treating diseases related to membrane fusion.
How similar studies have performed: Other research has shown success in understanding membrane fusion mechanisms, but this study aims to provide novel insights into specific protein interactions and structures.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, KELLY KEISEN — UNIVERSITY OF WASHINGTON
- Study coordinator: LEE, KELLY KEISEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus