Understanding how proteins help assemble DNA packaging
Histone chaperone networks for new and evicted histones
This study looks at special proteins that help organize DNA in our cells, which is important for keeping our genetic information safe and working properly, and it aims to understand how these proteins do their job during important processes like copying DNA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11098262 on NIH RePORTER |
What this research studies
This research investigates the role of histone chaperone proteins in the assembly and maintenance of chromatin, which is essential for DNA packaging. It focuses on how these proteins manage both new histones and those that are evicted during processes like DNA replication and transcription. By examining the interactions and functions of these chaperones, the research aims to uncover the mechanisms that ensure proper histone deposition and stability. This could lead to insights into how genetic information is accessed and regulated in cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or conditions that may be influenced by chromatin assembly and regulation.
Not a fit: Patients with conditions unrelated to chromatin dynamics or histone function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and potentially lead to new therapies for diseases linked to chromatin dysfunction.
How similar studies have performed: Other research has shown promising results in understanding histone chaperone functions, indicating that this approach has potential for significant findings.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Foltz, Daniel Richard — Northwestern University at Chicago
- Study coordinator: Foltz, Daniel Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.