Understanding how proteins help assemble DNA packaging
Histone chaperone networks for new and evicted histones
This study is looking at special proteins that help organize DNA in our cells, making sure everything stays in order and works properly, which is important for keeping our genes healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10879103 on NIH RePORTER |
What this research studies
This research investigates the role of histone chaperone proteins in the assembly and maintenance of chromatin, which is essential for DNA packaging in cells. It focuses on how these proteins manage both new histones and those that are evicted during processes like DNA replication and transcription. By exploring the interactions and functions of these chaperones, the research aims to uncover mechanisms that ensure proper histone supply and stability, which are crucial for maintaining genetic integrity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers that may be linked to chromatin assembly and histone modifications.
Not a fit: Patients with conditions unrelated to chromatin biology or histone function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic regulation and potential therapies for diseases related to chromatin dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding histone chaperone functions, indicating that this approach has potential for significant insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Foltz, Daniel Richard — Northwestern University at Chicago
- Study coordinator: Foltz, Daniel Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.