Understanding how proteins function in the retina using advanced chemical techniques
Official title: Functional Ocular Chemoproteomics for Retinal Biology Insight and in vivo Enzyme Activity
Funded at University of Minnesota · NIH-10815740 · Data updated 2026-11-12
This study is looking at how certain proteins in the eye work differently when someone is healthy compared to when they have eye diseases, and it hopes to find new ways to help treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | November 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $193,750 |
| NIH project number | 5R21EY032693-03 |
| Project ID | NIH-10815740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with retinal diseases or conditions that affect retinal function.
✕Less likely to help
Patients with non-retinal related conditions or those without any ocular diseases may not benefit from this research.
What this research studies
This research investigates the functional activity of proteins in the retina, focusing on how these proteins behave in both healthy and diseased states. By employing a method called activity-based protein profiling (ABPP), the study aims to provide insights into the mechanisms that govern protein function, which can be influenced by various factors such as cellular environment and the presence of specific molecules. Patients may benefit from this research as it could lead to the identification of new therapeutic targets for retinal diseases, enhancing our understanding of how to treat these conditions effectively.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for retinal diseases by identifying key proteins involved in disease processes.
How similar studies have gone: Other research using activity-based protein profiling has shown promise in understanding protein functions, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Hulleman, John Douglas — University of Minnesota
- Study coordinator: Hulleman, John Douglas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.