Understanding how proteins form disulfide bonds in the cell's cytoplasm
Protein Disulfide Bond Formation in the Reducing Environment of Cytoplasm
This study is looking at how a substance called hydrogen peroxide affects certain proteins in our cells, which is important for keeping them working properly, and it’s especially for people interested in understanding how these processes might impact health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10439311 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cysteine oxidation in proteins within the reducing environment of the cytoplasm. It focuses on how hydrogen peroxide affects these processes and the role of specific proteins, such as peroxiredoxins, in regulating cellular functions. By studying a newly identified form of peroxiredoxin in the cytosol, the research aims to uncover how these proteins contribute to disulfide bond formation, which is crucial for protein function. The team utilizes a knockout mouse model to explore the physiological implications of these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or oxidative stress, such as certain cancers or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to protein function or oxidative stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into protein regulation that may improve treatments for various diseases, including cancers and cardiovascular disorders.
How similar studies have performed: Previous research has shown success in understanding redox regulation in other cellular contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Lubbock, United States
- Texas Tech University — Lubbock, United States (Active)
Researchers
- Principal investigator: Yim, Sun Hee — Texas Tech University
- Study coordinator: Yim, Sun Hee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.