Understanding how proteins fold and move in cells
Coordination of chaperone interactions that dictate protein folding and trafficking
This study is looking at how proteins in our cells get help from special helpers called chaperones to fold and move correctly, and it aims to find out what happens when this process goes wrong, which can lead to diseases like Alzheimer's and Parkinson's, so that we can discover ways to keep our proteins healthy and prevent these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11011630 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between proteins and the chaperones that assist in their proper folding and movement within cells. By using advanced techniques in chemical biology and quantitative proteomics, the study aims to uncover how these interactions can go awry, leading to diseases like Alzheimer's and Parkinson's. The research focuses on the dynamics of protein folding and trafficking, which are crucial for maintaining cellular health and preventing misfolded proteins from causing harm. Patients may benefit from insights gained into how to improve protein quality control in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodegenerative diseases such as Alzheimer's or Parkinson's, as well as those with conditions related to protein misfolding.
Not a fit: Patients with conditions unrelated to protein folding or trafficking may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases by enhancing protein folding and trafficking mechanisms.
How similar studies have performed: Other research has shown promising results in understanding protein folding mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Plate, Lars — Vanderbilt University
- Study coordinator: Plate, Lars
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.