Understanding how proteins fold and function in cells
Molecular Mechanisms of Membrane Protein Misfolding and Quality Control in Cellular Proteostasis
['FUNDING_OTHER'] · PURDUE UNIVERSITY · NIH-11038009
This study is looking at how our cells make sure proteins are shaped correctly, especially those that sit in cell membranes, and it’s especially important for people with conditions like cystic fibrosis, as it helps us understand how mistakes in this process can lead to health problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-11038009 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind protein folding and quality control within cells, focusing on integral membrane proteins that are crucial for various biological functions. It aims to understand how cells maintain protein balance and how mutations can disrupt this process, leading to diseases like cystic fibrosis. The study employs advanced techniques to analyze the interactions between newly formed proteins and quality control proteins in the endoplasmic reticulum. By exploring these interactions, the research seeks to uncover the underlying causes of protein misfolding and its implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations that affect protein folding, particularly those with cystic fibrosis.
Not a fit: Patients with conditions unrelated to protein misfolding or those without genetic mutations affecting protein function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic diseases caused by protein misfolding, such as cystic fibrosis.
How similar studies have performed: Previous research has shown success in understanding protein misfolding and its implications for diseases, indicating that this approach has potential for meaningful advancements.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHLEBACH, JONATHAN PATRICK — PURDUE UNIVERSITY
- Study coordinator: SCHLEBACH, JONATHAN PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.