Understanding how proteins fold and function in cells
Official title: Molecular Mechanisms of Membrane Protein Misfolding and Quality Control in Cellular Proteostasis
Funded at Purdue University · NIH-11038009 · Data updated 2026-11-12
This study is looking at how our cells make sure proteins are shaped correctly, especially those that sit in cell membranes, and it’s especially important for people with conditions like cystic fibrosis, as it helps us understand how mistakes in this process can lead to health problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $588,613 |
| NIH project number | 5R35GM152086-02 |
| Project ID | NIH-11038009 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations that affect protein folding, particularly those with cystic fibrosis.
✕Less likely to help
Patients with conditions unrelated to protein misfolding or those without genetic mutations affecting protein function may not benefit from this research.
What this research studies
This research investigates the mechanisms behind protein folding and quality control within cells, focusing on integral membrane proteins that are crucial for various biological functions. It aims to understand how cells maintain protein balance and how mutations can disrupt this process, leading to diseases like cystic fibrosis. The study employs advanced techniques to analyze the interactions between newly formed proteins and quality control proteins in the endoplasmic reticulum. By exploring these interactions, the research seeks to uncover the underlying causes of protein misfolding and its implications for health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic diseases caused by protein misfolding, such as cystic fibrosis.
How similar studies have gone: Previous research has shown success in understanding protein misfolding and its implications for diseases, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Schlebach, Jonathan Patrick — Purdue University
- Study coordinator: Schlebach, Jonathan Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.