Understanding how proteins fix DNA errors to prevent cancer and infertility
Roles for Mismatch Repair Proteins in Maintaining Genome Stability
This study is looking at how certain proteins help fix mistakes in our DNA that can cause health issues like hereditary colon cancer and infertility, and it aims to create models to better understand how these proteins work in both healthy and diseased cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10985544 on NIH RePORTER |
What this research studies
This research investigates the role of mismatch repair (MMR) proteins in correcting errors that occur during DNA replication, which can lead to genetic disorders and cancers. By studying how these proteins recognize and repair mismatches in DNA, the research aims to develop molecular models that explain their functions in both normal cellular processes and disease states. The project will involve laboratory experiments to test these models and understand the implications of MMR defects on human health, particularly in relation to hereditary colon cancer and infertility.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of hereditary colon cancer or those experiencing infertility issues potentially related to genetic factors.
Not a fit: Patients without a family history of hereditary colon cancer or those whose infertility is not suspected to be linked to genetic defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for hereditary cancers and infertility linked to DNA repair mechanisms.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms and their implications for cancer, indicating that this approach is built on established scientific principles.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Alani, Eric E. — Cornell University
- Study coordinator: Alani, Eric E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.