Understanding how proteins fix DNA errors and help cells adapt to stress
Roles for Mismatch Repair Proteins in Maintaining Genome Stability
This study looks at how certain proteins help keep DNA stable and work properly in baker's yeast, which could teach us more about how our cells divide correctly and adapt to stress, helping us understand genetic stability and its link to diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11011284 on NIH RePORTER |
What this research studies
This research investigates the roles of mismatch repair (MMR) proteins in maintaining the stability of DNA and how they contribute to genetic recombination and stress adaptation. By studying baker’s yeast, the research aims to uncover the mechanisms behind the accurate segregation of chromosomes during cell division, which is crucial for forming gametes. The team is developing methods to map DNA damage and repair processes, which could provide insights into how these proteins function in both normal and stressed conditions. This work may lead to a better understanding of genetic stability and its implications for various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions related to DNA repair mechanisms or those at risk for cancers associated with chromosomal instability.
Not a fit: Patients with conditions unrelated to DNA repair or chromosomal stability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic stability, potentially leading to improved treatments for cancers and other genetic disorders.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms in model organisms, indicating that this approach has the potential for significant findings.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Alani, Eric E. — Cornell University
- Study coordinator: Alani, Eric E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.