Understanding how proteins evolve new functions over time
Genetic and biophysical causes of historical protein evolution
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-10864060
This study is looking at how proteins change and gain new abilities over time, which could help us find new ways to treat diseases caused by problems with proteins, so it’s important for anyone interested in better health solutions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10864060 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and biophysical factors that contribute to the evolution of proteins, focusing on how existing proteins acquire new functions. By utilizing ancestral protein reconstruction and deep mutational scanning, the team aims to explore the evolutionary pathways that proteins have taken and the various factors influencing these changes. Patients may benefit from insights gained about protein functions that could lead to new therapeutic targets or treatments for diseases related to protein dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with genetic disorders or diseases linked to protein malfunctions.
Not a fit: Patients with conditions unrelated to protein function or evolution may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases caused by dysfunctional proteins.
How similar studies have performed: Previous research has shown success in understanding protein evolution through similar methodologies, indicating a promising avenue for further exploration.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THORNTON, JOSEPH W — UNIVERSITY OF CHICAGO
- Study coordinator: THORNTON, JOSEPH W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.