Understanding how proteins control the release of substances from cells
Discovering protein networks underlying regulated exocytosis
This study is looking at how certain proteins help cells release insulin in response to sugar, which is important for people with diabetes, and aims to find new ways to understand and improve this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11056157 on NIH RePORTER |
What this research studies
This research investigates the complex protein networks that regulate exocytosis, which is the process by which cells release substances in response to stimuli. By focusing on insulin-stimulated GLUT4 exocytosis, the study aims to identify new regulators involved in this critical biological function. The researchers will utilize advanced techniques, including CRISPR genetic screens and biochemical studies, to explore how these proteins interact and how their functions are linked to other cellular processes. This work could provide insights into the mechanisms behind various diseases caused by imbalances in exocytosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to exocytosis imbalances, such as diabetes or metabolic disorders.
Not a fit: Patients with conditions unrelated to cellular signaling or exocytosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to exocytosis dysfunction, such as diabetes and certain cancers.
How similar studies have performed: Previous research has shown promising results in understanding exocytosis mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Shen, Jingshi — University of Colorado
- Study coordinator: Shen, Jingshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.