Understanding how proteins control heart development and left-right body patterning
A protein traffic control system that regulates left-right patterning and heart development
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10910878
This study is looking at how certain problems in a specific protein system can cause congenital heart defects and other issues in the body, with the hope that the findings will help improve diagnosis and treatment for patients with these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10910878 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind congenital heart defects (CHDs) and their association with left-right patterning issues in the body. By studying a specific protein traffic control system, known as the MMM pathway, the researchers aim to uncover how disruptions in this pathway can lead to severe heart defects and other developmental anomalies. The approach combines insights from mouse models and human genetic data to explore the impact of these mechanisms on heart and organ development. Patients may benefit from improved diagnostic and therapeutic strategies based on the findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants diagnosed with congenital heart defects or those with a family history of such conditions.
Not a fit: Patients with congenital heart defects that are not associated with left-right patterning issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for congenital heart defects in infants.
How similar studies have performed: Previous research has shown promising results in understanding congenital heart defects through similar molecular pathways, indicating potential for success in this approach.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROHATGI, RAJAT — STANFORD UNIVERSITY
- Study coordinator: ROHATGI, RAJAT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.