Understanding how proteins control gene instructions
Function of Sequence-specific RNA Binding Proteins
['FUNDING_R01'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-11056900
This work aims to discover the basic rules that guide how our genes make different versions of proteins, which is important for our body's health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11056900 on ClinicalTrials.gov |
What this research studies
Our bodies use a process called alternative splicing to create many different proteins from a single gene, which is like having one recipe that can make several unique dishes. This process is carefully managed by special proteins called splicing factors that attach to specific parts of our genetic code. We are working to understand the precise instructions these splicing factors follow to control which protein versions are made. By creating detailed 'RNA maps,' we hope to learn how these factors work and how their actions are determined by their own protein makeup and interactions with other factors.
Who could benefit from this research
Good fit: This foundational work does not directly involve patients, but future applications could benefit individuals with conditions linked to errors in gene splicing.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this basic understanding could help us better understand diseases caused by errors in gene splicing and potentially lead to new ways to correct them.
How similar studies have performed: While the concept of alternative splicing is well-established, this project aims to develop novel, more detailed 'RNA maps' and understanding of splicing factor activity.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BURGE, CHRISTOPHER B — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: BURGE, CHRISTOPHER B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.