Understanding how proteins control gene expression
Defining the protein sequence features that control transcriptional activation domain function
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10890714
This study is looking at how certain proteins help turn genes on and off, using special lab techniques to see how changes in these proteins can affect their shape and function, which could help us better understand how genes work in our bodies.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10890714 on ClinicalTrials.gov |
What this research studies
This research investigates the specific protein sequences that influence how transcription factors activate gene expression. By using advanced techniques such as high-throughput assays in yeast and human cell cultures, the team will design mutations to test their hypotheses about protein function. Additionally, they will employ biophysical simulations and machine learning to analyze how these mutations affect the 3D structures of proteins. The goal is to enhance our understanding of gene regulation, which could lead to better predictions of gene expression from genetic sequences.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases linked to gene expression abnormalities.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting gene expression, which may enhance the development of targeted therapies for various diseases.
How similar studies have performed: Other research has shown promising results in understanding gene regulation through similar approaches, indicating potential for success in this area.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STALLER, MAX VALENTIN — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: STALLER, MAX VALENTIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.