Understanding how proteins control gene accessibility in cells
Unraveling the Dynamic Competition Between Activating and Repressive Complexes in Shaping Chromatin Accessibility
['FUNDING_CAREER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10948740
This study looks at how two types of protein complexes work together to control whether genes are active or inactive, which is important for understanding how certain diseases, like cancer and developmental disorders, happen.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10948740 on ClinicalTrials.gov |
What this research studies
This research investigates the competition between two types of protein complexes that regulate chromatin accessibility, which is crucial for gene expression. By examining how these complexes interact and influence each other, the study aims to uncover the underlying mechanisms that dictate whether genes are turned on or off. The research employs advanced microscopy and biochemical techniques to analyze these dynamics in both healthy and diseased cells. This could lead to a better understanding of how mutations in these complexes contribute to various diseases, including cancers and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting chromatin-modifying complexes, particularly those with cancers or developmental disorders.
Not a fit: Patients without genetic mutations related to chromatin accessibility or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into new therapeutic strategies for diseases caused by chromatin dysregulation.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIEKAMP, STEFAN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: NIEKAMP, STEFAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers