Understanding how proteins control cell division and gene expression in cancer
Cyclin-dependent kinase control of cell-division and transcription cycles
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11035187
This study is looking at how certain proteins help control the process of making RNA, which is important for producing the genes that can affect cancer growth, and it hopes to find new ways to develop treatments for cancer by understanding these proteins better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11035187 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cyclin-dependent kinases (CDKs) and phosphatases in regulating the transcription cycle of RNA polymerase II, which is crucial for mRNA synthesis. By exploring how these proteins interact and influence gene expression, the research aims to uncover potential drug targets for cancer therapy. The team will analyze how specific modifications to these proteins affect their function and the overall process of cell division. This could lead to new strategies for disrupting cancer cell growth.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who may benefit from new therapeutic approaches targeting CDKs and phosphatases.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not influenced by the mechanisms being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel anti-cancer therapies that target the mechanisms controlling cell division and gene expression.
How similar studies have performed: Previous research has shown that targeting CDKs and phosphatases can be effective in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FISHER, ROBERT P — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: FISHER, ROBERT P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, cancer cell, cancer therapy, Cancer Treatment, cancer-directed therapy