Understanding How Proteins Connect in Our Bodies
Comprehensive Analysis of Peptide Motif Binding In Vivo
This research aims to understand how different proteins in our cells connect and interact, which is vital for healthy body function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11162284 on NIH RePORTER |
What this research studies
Our cells rely on countless interactions between proteins to work correctly, especially those quick and temporary connections. Often, these connections happen when a folded part of one protein links up with a short sequence, called a Short Linear Motif (SLiM), on another protein. While we know some about these SLiMs, many of their specific roles and how they recognize their partners are still a mystery. This project will develop new ways to measure the strength of these protein connections, helping us better understand how they work.
Who could benefit from this research
Good fit: This foundational biological research does not involve direct patient participation, but it focuses on processes relevant to all human biology.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of these fundamental protein interactions could eventually lead to new ways to address diseases caused by faulty cell communication.
How similar studies have performed: While some specific protein interactions have been studied in detail, this project aims to fill significant gaps in our overall knowledge of how these widespread connections function.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Pryciak, Peter M — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Pryciak, Peter M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.