Understanding how proteins change to create new drugs
Official title: Molecular Mechanisms Remodeling Dynamic Landscapes in Multidomain Enzymatic Factories
Funded at Johns Hopkins University · NIH-11011175 · Data updated 2026-11-12
This study is looking at how certain important proteins work together and change shape, which could help scientists create better medicines, like antibiotics and cancer treatments, for people who need them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $450,313 |
| NIH project number | 1R35GM156407-01 |
| Project ID | NIH-11011175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with conditions that could benefit from new antibiotic or anti-cancer therapies.
✕Less likely to help
Patients with conditions unrelated to antibiotic resistance or cancer may not receive any benefit from this research.
What this research studies
This research investigates the dynamic behavior of multidomain proteins, specifically focusing on nonribosomal peptide synthetases (NRPSs) that are crucial for synthesizing complex natural products with therapeutic benefits. By using advanced techniques like nuclear magnetic resonance (NMR) spectroscopy and computational modeling, the team aims to uncover how different protein domains interact and change, which can lead to the development of improved pharmaceuticals, including antibiotics and anti-cancer agents. The goal is to create a deeper understanding of protein dynamics to facilitate the engineering of these proteins for better drug design.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antibiotics and anti-cancer drugs.
How similar studies have gone: Other research has shown promise in engineering proteins for drug development, indicating that this approach could yield significant advancements.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Frueh, Dominique Pascal — Johns Hopkins University
- Study coordinator: Frueh, Dominique Pascal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.