Understanding how proteins change their function in response to signals
Official title: Mapping and Exploiting the Internal Wiring of Structurally Dynamic Phosphatases
Funded at Advanced Science Research Center · NIH-11011728 · Data updated 2026-11-12
This study is looking at how certain proteins in our bodies change their behavior when they receive signals, which could help scientists create new medications for diseases like Alzheimer's that might work better for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Advanced Science Research Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2019 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $395,000 |
| NIH project number | 2R35GM133769-06 |
| Project ID | NIH-11011728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related conditions that involve Protein Tyrosine Phosphatases.
✕Less likely to help
Patients with conditions unrelated to Protein Tyrosine Phosphatases or those not diagnosed with Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the mechanisms by which proteins, specifically Protein Tyrosine Phosphatases (PTPs), alter their functions in response to cellular signals through a process called allostery. By employing advanced experimental techniques like X-ray crystallography and computational algorithms, the researchers aim to uncover the differences in how related proteins respond to signals. This understanding could lead to the development of new small-molecule drugs that target specific proteins involved in diseases such as Alzheimer's. Patients may benefit from insights gained into how these proteins can be modulated to improve treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating conditions like Alzheimer's disease by targeting specific proteins involved in the disease process.
How similar studies have gone: Previous research has shown promise in understanding allosteric mechanisms in proteins, suggesting that this approach could yield significant insights.
Where this research is happening
-
Advanced Science Research Center
New York, United States Active
Researchers
- Principal investigator: Keedy, Daniel a — Advanced Science Research Center
- Study coordinator: Keedy, Daniel a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.