Understanding how proteins change structure in diseases
Official title: Rapid Assessment of Proteoform-Resolved Higher-Order Structures
Funded at University of Nevada Reno · NIH-10930829 · Data updated 2026-11-12
This study is looking at how proteins change shape and how these changes can be influenced by chemical changes, especially in diseases like cancer and heart problems, to help find better ways to diagnose and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | September 20, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $359,248 |
| NIH project number | 5R35GM151104-02 |
| Project ID | NIH-10930829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancers, neurodegenerative disorders, or cardiovascular diseases.
✕Less likely to help
Patients with non-disease-related conditions or those without any protein-related disorders may not benefit from this research.
What this research studies
This research investigates how proteins fold into complex structures and how these structures are affected by chemical modifications, particularly in the context of diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. By using advanced techniques such as mass spectrometry, the project aims to characterize these protein structures and their modifications, which can help in diagnosing diseases and developing targeted therapies. The goal is to improve our understanding of cellular functions and disease mechanisms, ultimately leading to better treatment options for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for various diseases.
How similar studies have gone: Previous research has shown promise in using mass spectrometry to analyze protein structures, indicating that this approach could be effective.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Borotto, Nicholas Brent — University of Nevada Reno
- Study coordinator: Borotto, Nicholas Brent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.