Understanding how proteins change shape and function
Official title: Functional Protein Conformations and Dynamics via Transparent Window 1D & 2D Infrared Spectroscopy
Funded at Trustees of Indiana University · NIH-11054652 · Data updated 2026-11-12
This study looks at how proteins change shape quickly and how those changes affect their work in the body, which could help us understand diseases better and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | May 5, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $352,690 |
| NIH project number | 5R35GM148290-03 |
| Project ID | NIH-11054652 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions linked to protein misfolding or dysfunction, such as certain genetic disorders or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein dynamics or those who do not have a genetic or biochemical basis for their illness may not receive direct benefits from this research.
What this research studies
This research investigates the dynamic behavior of proteins, which are essential for various cellular processes. By using advanced infrared spectroscopy techniques, the study aims to capture the rapid changes in protein conformations that are crucial for their function. The researchers will explore how these conformational changes affect protein interactions and activities, which could lead to a deeper understanding of biological processes and disease mechanisms. Patients may benefit from insights gained into protein behavior that could inform new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases related to protein dysfunction and inform the development of targeted therapies.
How similar studies have gone: Previous research has shown success in using infrared spectroscopy to study protein dynamics, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Thielges, Megan Corrine — Trustees of Indiana University
- Study coordinator: Thielges, Megan Corrine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.