Understanding how proteins change shape and function
Functional Protein Conformations and Dynamics via Transparent Window 1D & 2D Infrared Spectroscopy
['FUNDING_OTHER'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-11054652
This study looks at how proteins change shape quickly and how those changes affect their work in the body, which could help us understand diseases better and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-11054652 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic behavior of proteins, which are essential for various cellular processes. By using advanced infrared spectroscopy techniques, the study aims to capture the rapid changes in protein conformations that are crucial for their function. The researchers will explore how these conformational changes affect protein interactions and activities, which could lead to a deeper understanding of biological processes and disease mechanisms. Patients may benefit from insights gained into protein behavior that could inform new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions linked to protein misfolding or dysfunction, such as certain genetic disorders or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein dynamics or those who do not have a genetic or biochemical basis for their illness may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases related to protein dysfunction and inform the development of targeted therapies.
How similar studies have performed: Previous research has shown success in using infrared spectroscopy to study protein dynamics, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THIELGES, MEGAN CORRINE — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: THIELGES, MEGAN CORRINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.