Understanding how proteins change in response to environmental factors
Official title: Spatially resolved characterization of proteoforms for functional proteomics
Funded at Battelle Pacific Northwest Laboratories · NIH-10889043 · Data updated 2026-11-12
This study is looking at how changes to proteins in our cells can influence gene activity and lead to diseases, especially when these proteins are affected by environmental toxins, to help find better ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | September 8, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $600,000 |
| NIH project number | 5UH3CA256959-04 |
| Project ID | NIH-10889043 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals exposed to environmental toxins or those with conditions influenced by protein modifications.
✕Less likely to help
Patients with conditions unrelated to protein alterations or those not exposed to environmental factors may not benefit from this research.
What this research studies
This research investigates the patterns of protein modifications in human cells, particularly focusing on how these changes can affect gene expression and contribute to diseases. Using advanced mass spectrometry techniques, the study aims to analyze proteins in their complete forms without breaking them down, allowing for a more accurate understanding of their functions. By examining how proteins are altered by environmental toxins, the research seeks to uncover critical insights into disease mechanisms and potential recovery strategies.
Why it matters
Potential benefit: If successful, this research could lead to new methods for diagnosing and treating diseases linked to protein alterations.
How similar studies have gone: Previous research using mass spectrometry for protein analysis has shown promising results, indicating that this approach could yield significant insights into disease mechanisms.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Pasa-Tolic, Ljiljana — Battelle Pacific Northwest Laboratories
- Study coordinator: Pasa-Tolic, Ljiljana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.