Understanding how proteins change in aging and Alzheimer's disease
Proteomics and Post-translational Modification
This study is looking at how tiny parts of our cells called lysosomes help keep proteins balanced and working well, especially as we age or in conditions like Alzheimer's disease, with the hope that understanding these changes can lead to better treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11051218 on NIH RePORTER |
What this research studies
This research investigates the role of lysosomes, which are essential cellular organelles, in maintaining protein balance and signaling within cells. By examining how protein expression and modifications change during aging and in Alzheimer's disease, the study aims to uncover the underlying mechanisms that contribute to these conditions. The research utilizes advanced proteomic techniques to analyze lysosomal proteins and their modifications, providing insights into how these changes affect cellular function and gene regulation. Patients may benefit from a better understanding of the biological processes involved in age-related diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with early-stage cognitive impairment not related to aging or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for age-related diseases like Alzheimer's, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding protein modifications in aging and neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Young, Nicolas L — Baylor College of Medicine
- Study coordinator: Young, Nicolas L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.