Understanding how proteins change during cell differentiation
Investigations of Proteome Turnover Kinetics Under Cellular Differentiation
This study is looking at how proteins change when special stem cells turn into different types of cells, like heart, liver, and nerve cells, which could help us understand diseases better and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11060844 on NIH RePORTER |
What this research studies
This research investigates the dynamic processes of protein turnover during the differentiation of human induced pluripotent stem cells (iPSCs) into various cell types, including heart, liver, and nerve cells. By using advanced techniques like deuterium stable isotope labeling and mass spectrometry, the study aims to create a detailed timeline of protein changes that occur as cells transition from one state to another. This approach could reveal new insights into how cells develop and function, potentially identifying novel disease markers and therapeutic targets. Patients may benefit from the findings as they could lead to improved treatments for conditions related to these cell types.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions affecting cardiac, hepatic, or neurological functions.
Not a fit: Patients with unrelated conditions or those not affected by diseases of the heart, liver, or nervous system may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases related to heart, liver, and nerve cells.
How similar studies have performed: Other research has successfully utilized similar methodologies to study protein dynamics, suggesting a promising avenue for this investigation.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Lau, Edward — University of Colorado Denver
- Study coordinator: Lau, Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.