Understanding how proteins change during cell differentiation
Investigations of proteome turnover kinetics under cellular differentiation
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10894210
This study is looking at how proteins change when stem cells turn into different types of cells, like heart and liver cells, to help us understand more about how our bodies work and find new clues for diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10894210 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic changes in protein levels as cells differentiate into specific types, such as heart and liver cells. By using advanced techniques like deuterium stable isotope labeling and mass spectrometry, the study aims to create detailed maps of protein turnover during the differentiation of human induced pluripotent stem cells (iPSCs). The goal is to uncover novel cell states and potential disease markers by analyzing how proteins are synthesized and degraded at different stages of cell development. This could lead to a better understanding of cellular processes and their implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in stem cell therapies or those affected by conditions related to heart or liver cells.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular differentiation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cell differentiation that may improve treatments for various diseases.
How similar studies have performed: Previous research using similar methods has shown promise in understanding protein dynamics, suggesting potential for success in this novel approach.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAU, EDWARD — UNIVERSITY OF COLORADO DENVER
- Study coordinator: LAU, EDWARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.