Understanding how proteins change cell types
Transcription Factors Overcoming Chromatin Barriers to Control Cell Fate
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11046607
This study is looking at how certain proteins can help change the way cells behave, which could lead to new ways to create different types of cells for treatments and understanding diseases better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11046607 on ClinicalTrials.gov |
What this research studies
This research investigates how specific proteins, known as transcription factors, can overcome structural barriers in chromosomes to change the fate of cells. By studying the interactions between these factors and chromatin, the research aims to uncover new methods for generating different cell types that could be used in therapies and disease modeling. The approach combines various techniques, including biochemical assays and genomic sequencing, to provide insights into gene regulation and cellular reprogramming.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from cell-based therapies, such as degenerative diseases or injuries requiring tissue regeneration.
Not a fit: Patients with conditions that do not involve cell differentiation or reprogramming may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more efficient methods for creating new cell types for therapeutic use.
How similar studies have performed: Previous research has shown promising results in understanding transcription factors and their role in cell fate changes, indicating that this approach has potential for success.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZARET, KENNETH — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: ZARET, KENNETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.