Understanding how proteins bind to DNA and affect its structure during cell division
Official title: Visualizing transcription factor binding and chromatin assembly on newly synthesized DNA
Funded at Fred Hutchinson Cancer Center · NIH-10993189 · Data updated 2026-11-12
This study is looking at how certain proteins that help control genes attach to new DNA and shape its structure, which could help us understand how problems with this process might lead to diseases like cancer and guide the creation of new treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $125,000 |
| NIH project number | 5K99GM152821-02 |
| Project ID | NIH-10993189 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or genetic conditions that may be influenced by chromatin structure and gene expression.
✕Less likely to help
Patients with conditions unrelated to chromatin structure or gene expression may not benefit from this research.
What this research studies
This research investigates the mechanisms by which transcription factors, proteins that regulate gene expression, bind to newly synthesized DNA and influence chromatin structure. By using advanced techniques like Nascent CUT&Tag and Nascent Fiber-seq, the study aims to uncover the timing and methods of transcription factor binding during DNA replication and chromatin maturation. This knowledge could help clarify how improper chromatin structure can lead to diseases, including cancer, and may inform the development of new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of gene regulation and potential new treatments for cancer and other diseases linked to chromatin structure.
How similar studies have gone: Other research has shown success in understanding chromatin dynamics and transcription factor interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Wooten, Matthew — Fred Hutchinson Cancer Center
- Study coordinator: Wooten, Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.