Understanding how proteins bind to DNA
Deconvolving the language of protein binding
['FUNDING_OTHER'] · CORNELL UNIVERSITY · NIH-11129907
This study is looking at how certain proteins in our cells connect with DNA, which helps control how our genes work, and it aims to find out how these connections can affect health, potentially helping patients understand diseases caused by these miscommunications.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CORNELL UNIVERSITY (nih funded) |
| Locations | 1 site (ITHACA, UNITED STATES) |
| Trial ID | NIH-11129907 on ClinicalTrials.gov |
What this research studies
This research investigates how transcription factors, which are proteins that regulate gene expression, specifically bind to DNA in the nucleus. By using advanced robotic systems and machine learning algorithms, the study aims to uncover the complex rules that govern protein-DNA interactions, taking into account various biological factors that can influence binding. The research will utilize high-throughput genomic assays to analyze these interactions in human cells, providing insights into the mechanisms of gene regulation. Patients may benefit from a better understanding of how mis-targeting of protein binding can lead to diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or diseases linked to transcription factor malfunctions.
Not a fit: Patients with conditions unrelated to gene regulation or transcription factor activity may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by improper gene regulation.
How similar studies have performed: Previous research using similar high-throughput genomic assays has shown success in understanding protein-DNA interactions in model organisms, suggesting potential for success in human studies.
Where this research is happening
ITHACA, UNITED STATES
- CORNELL UNIVERSITY — ITHACA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAI, WILLIAM — CORNELL UNIVERSITY
- Study coordinator: LAI, WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.