Understanding how proteins behave inside living cells
Official title: Protein Structural Dynamics in Living Cells
Funded at Yale University · NIH-10911286 · Data updated 2026-11-12
This study is looking at how proteins work inside living cells and how they interact with their surroundings, which is important for understanding diseases better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $418,750 |
| NIH project number | 5R35GM151146-02 |
| Project ID | NIH-10911286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein dynamics or those who do not have any protein-related disorders may not benefit from this research.
What this research studies
This research investigates the dynamics of protein behavior within living cells, focusing on how proteins interact with their environment and other biomolecules. By utilizing advanced spectro-microscopy techniques and biochemical assays, the study aims to uncover the fundamental principles governing protein folding and function in vivo. The goal is to bridge the gap in knowledge regarding how cellular interactions affect protein stability and dynamics, which is crucial for understanding various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new insights into protein-related diseases and improve therapeutic strategies.
How similar studies have gone: Other research has shown success in understanding protein dynamics using similar spectroscopic techniques, indicating a promising avenue for further exploration.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Davis, Caitlin — Yale University
- Study coordinator: Davis, Caitlin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.