Understanding how proteins behave in living cells
Mapping endogenous protein dynamics in living cells
This study is all about watching how proteins work inside living human cells using special imaging tools, which could help us understand more about how our cells function and what goes wrong in diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10930102 on NIH RePORTER |
What this research studies
This research focuses on mapping the dynamics of proteins within living human cells using advanced imaging techniques and CRISPR technology. By creating tagged cell lines, researchers can observe how proteins interact and function in real-time, providing insights into their roles in cellular processes. The study aims to enhance long-term imaging capabilities to capture detailed protein behavior while minimizing damage to the cells. This innovative approach could lead to a better understanding of cellular mechanisms and disease processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein dysfunction or cellular signaling abnormalities.
Not a fit: Patients with stable conditions unrelated to protein dynamics or cellular processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding diseases at the molecular level, potentially informing new treatment strategies.
How similar studies have performed: Previous research using CRISPR and advanced imaging techniques has shown promise in understanding protein dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Huang, Bo — University of California, San Francisco
- Study coordinator: Huang, Bo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.