Understanding how proteins assemble to perform cellular functions
Official title: Mechanisms of septin assembly that shape cellular function
Funded at University of Colorado Denver · NIH-11247233 · Data updated 2026-11-12
This study is looking at how certain proteins called septins come together to form important structures in cells, using yeast to help us understand how this process works, which could give us insights into how our cells function and stay healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $65,965 |
| NIH project number | 3R35GM148198-03S1 |
| Project ID | NIH-11247233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with genetic conditions related to septin dysfunction or those interested in cellular biology.
✕Less likely to help
Patients with conditions unrelated to cellular assembly or septin function may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which septin proteins, essential components of cellular structures, assemble into functional complexes. Using budding yeast as a model organism, the study aims to uncover how specific septin subunits are selected and organized within these complexes, which is crucial for proper cellular function. The research employs advanced molecular biology techniques to explore the role of molecular chaperones in facilitating this assembly process. By addressing these fundamental questions, the research seeks to enhance our understanding of cellular biology and its implications for health.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular processes that may inform treatments for diseases linked to septin mutations.
How similar studies have gone: While the specific focus on septin assembly is relatively novel, similar research on protein complex assembly has shown promising results in understanding cellular functions.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Mcmurray, Michael a — University of Colorado Denver
- Study coordinator: Mcmurray, Michael a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.