Understanding how proteins assemble to perform cellular functions
Mechanisms of septin assembly that shape cellular function
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-11247233
This study is looking at how certain proteins called septins come together to form important structures in cells, using yeast to help us understand how this process works, which could give us insights into how our cells function and stay healthy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11247233 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which septin proteins, essential components of cellular structures, assemble into functional complexes. Using budding yeast as a model organism, the study aims to uncover how specific septin subunits are selected and organized within these complexes, which is crucial for proper cellular function. The research employs advanced molecular biology techniques to explore the role of molecular chaperones in facilitating this assembly process. By addressing these fundamental questions, the research seeks to enhance our understanding of cellular biology and its implications for health.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic conditions related to septin dysfunction or those interested in cellular biology.
Not a fit: Patients with conditions unrelated to cellular assembly or septin function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular processes that may inform treatments for diseases linked to septin mutations.
How similar studies have performed: While the specific focus on septin assembly is relatively novel, similar research on protein complex assembly has shown promising results in understanding cellular functions.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCMURRAY, MICHAEL A — UNIVERSITY OF COLORADO DENVER
- Study coordinator: MCMURRAY, MICHAEL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.