Understanding How Proteins Assemble Inside Cells
Using in vivo genetic and physical interaction data for structure determination of protein assemblies
This research aims to build detailed models of how proteins fit together and work within our cells, helping us better understand fundamental body functions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11128837 on NIH RePORTER |
What this research studies
Many important proteins in our bodies work by forming complex groups, but it's challenging to see exactly how they fit together within living cells. Traditional methods often require purified samples and might only show a few static pictures. This project uses new techniques that look at how proteins interact genetically and physically inside cells. By combining these clues, scientists can create more complete pictures of these protein groups, even as they change and adapt to their cellular environment. This approach helps address structural questions that are currently difficult to answer with older methods.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work will provide a deeper understanding of fundamental cellular processes, which could eventually lead to new ways to address diseases caused by protein malfunctions.
How similar studies have performed: The methods used, such as genetic interaction mapping and cross-linking mass-spectrometry, are powerful tools that have shown success in revealing protein details.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Echeverria Riesco, Ignacia — University of California, San Francisco
- Study coordinator: Echeverria Riesco, Ignacia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.