Understanding how proteins assemble in living cells
Using in vivo genetic and physical interaction data for structure determination of protein assemblies
This study is exploring how proteins work together in their natural settings inside cells, using advanced techniques to create detailed models that show how they interact and change, which will help scientists better understand their roles and tackle tough questions in biology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10900696 on NIH RePORTER |
What this research studies
This research investigates the structures of protein assemblies within their natural cellular environments, which is crucial for understanding their functions. By utilizing innovative techniques like in vivo genetic interaction mapping and quantitative cross-linking mass-spectrometry, the study aims to create detailed structural models of these proteins. This approach allows researchers to observe how proteins interact and change in response to different cellular conditions, providing insights that traditional methods cannot achieve. The goal is to empower scientists to tackle complex structural biology questions that are currently beyond reach.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic conditions or diseases related to protein misfolding or assembly.
Not a fit: Patients with conditions unrelated to protein assembly or those not affected by genetic factors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding protein functions and interactions, potentially informing new therapeutic strategies for various diseases.
How similar studies have performed: Other research has shown success using similar innovative approaches to study protein interactions and structures, indicating a promising avenue for further exploration.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Echeverria Riesco, Ignacia — University of California, San Francisco
- Study coordinator: Echeverria Riesco, Ignacia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.