Understanding how proteins are transported within cells using a coronavirus toolkit
Official title: Biophysical, Structural, and Cellular Dissection of COPI-Dependent Retrograde Trafficking Using a Coronavirus Toolkit
Funded at University of Maryland Baltimore · NIH-10934517 · Data updated 2026-11-12
This study is looking at how proteins move around inside our cells and how they can be recycled back to a part of the cell called the endoplasmic reticulum, which is important for keeping our cells healthy, and the findings could help people with autoimmune disorders and cancers understand their conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $411,570 |
| NIH project number | 5R01GM150187-02 |
| Project ID | NIH-10934517 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune disorders or cancers that may be related to protein trafficking issues.
✕Less likely to help
Patients who do not have conditions related to protein trafficking or autoimmune disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms of protein trafficking within cells, specifically focusing on how certain proteins are retrieved and recycled back to the endoplasmic reticulum (ER) using a coronavirus toolkit. By examining the interactions between specific proteins and the coatomer protein I complex (COPI), the study aims to uncover the atomic principles that govern these processes. This knowledge could help in understanding how disruptions in protein trafficking can lead to various diseases, including autoimmune disorders and cancers. Patients may benefit from insights gained about how to better manage conditions related to these dysfunctions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases linked to protein trafficking dysfunctions.
How similar studies have gone: Other research has shown success in understanding protein trafficking mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Hasan, Syed Saif — University of Maryland Baltimore
- Study coordinator: Hasan, Syed Saif
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.