Understanding how proteins are transported in heart cells during hypertrophy
Official title: Critical Sorting Steps and Pathways in the Trafficking of Cardiac Sarcoplasmic Reticulum Proteins
Funded at Indiana University Indianapolis · NIH-11062362 · Data updated 2026-11-12
This study is looking at how proteins move around in heart cells, especially when the heart is under stress, like in heart disease, to find new ways to help treat patients with heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | June 15, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $574,203 |
| NIH project number | 5R01HL169877-03 |
| Project ID | NIH-11062362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing cardiac hypertrophy or related cardiac disorders.
✕Less likely to help
Patients with non-cardiac related conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the distribution of proteins in heart cells, particularly during conditions like cardiac hypertrophy, which can lead to heart failure. The study focuses on how newly synthesized proteins are sorted and transported within the cells, using advanced techniques to analyze their movement and organization. By examining the early steps of protein trafficking in adult heart cells, the research aims to uncover critical regulatory sites that could be targeted for new therapies. This could ultimately help in developing better treatment options for patients with heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating cardiac hypertrophy and heart failure.
How similar studies have gone: While the specific mechanisms of protein trafficking in cardiac cells are not fully understood, similar research approaches have shown promise in other areas of cardiac biology.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Chen, Zhenhui — Indiana University Indianapolis
- Study coordinator: Chen, Zhenhui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.