Understanding how proteins are sorted and secreted in cells
Official title: Mechanism of secretory cargo sorting at the trans-Golgi Network (TGN)
Funded at Yale University · NIH-11055297 · Data updated 2026-11-12
This study is looking at how proteins are sorted and sent to the right places in our bodies, which is important for keeping our cells healthy, and it could help us understand how problems in this process might lead to diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $418,750 |
| NIH project number | 5R35GM149293-03 |
| Project ID | NIH-11055297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to protein secretion abnormalities, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to protein secretion or those who do not have a cellular or biochemical component to their illness may not benefit from this research.
What this research studies
This research investigates the mechanisms by which proteins are sorted and secreted from cells, focusing on the trans-Golgi Network (TGN). It aims to uncover how specific proteins are directed to their correct destinations within the body, which is crucial for maintaining healthy cellular functions. By exploring the role of liquid-liquid phase separation in organizing these processes, the study seeks to identify the signals and receptors involved in protein sorting. Patients may benefit from insights gained into how disruptions in these processes could lead to diseases, including cancers.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to protein secretion dysfunction.
How similar studies have gone: Other research has shown success in understanding protein sorting mechanisms, but this specific approach using liquid-liquid phase separation is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Von Blume, Julia — Yale University
- Study coordinator: Von Blume, Julia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.