Understanding how proteins are repaired and recycled in cells
Mechanisms of Protein Disaggregation and Turnover by AAA+ Chaperones
This study is looking at how certain helpers in our cells keep proteins healthy and balanced, especially when stress or aging causes problems that can lead to diseases like Alzheimer's, and the goal is to find new ways to prevent or treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10810802 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which proteins are disaggregated and turned over in cells, focusing on the role of specific chaperones that help maintain protein balance and cell health. It aims to uncover how these processes fail during stress and aging, leading to conditions like Alzheimer's disease. By using advanced imaging techniques, the study seeks to visualize the structures and functions of these protein machines, which could reveal new therapeutic targets for neurodegenerative diseases. Patients may benefit from insights gained into how to prevent or treat diseases associated with protein misfolding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or other neurodegenerative conditions.
Not a fit: Patients with neurodegenerative diseases unrelated to protein misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow the progression of neurodegenerative diseases like Alzheimer's.
How similar studies have performed: Other research has shown promising results in understanding protein disaggregation mechanisms, suggesting potential for breakthroughs in treating related diseases.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Southworth, Daniel Ryland — University of California, San Francisco
- Study coordinator: Southworth, Daniel Ryland
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.