Understanding how proteins are regulated through evolution
Evolutionary Origins of Protein Regulation
This study is looking at how proteins, like glucokinase, change over time and how these changes can affect their function, which might help us understand diseases caused by protein problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-10443565 on NIH RePORTER |
What this research studies
This research investigates the evolutionary origins of protein regulation, focusing on how changes in amino acid sequences can alter protein structures and their functions. By studying the glucokinase protein family, the research aims to uncover how evolutionary processes contribute to the development of new regulatory mechanisms in proteins. The approach involves reconstructing ancestral protein sequences to explore their conformational diversity and regulatory capabilities. This could provide insights into the fundamental principles of protein biology and their implications for diseases linked to protein mis-regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein mis-regulation, particularly those with diabetes.
Not a fit: Patients with conditions unrelated to protein regulation or those not affected by diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases caused by protein mis-regulation, such as diabetes.
How similar studies have performed: Previous research has shown success in understanding protein regulation through evolutionary approaches, indicating that this methodology is promising.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Miller, Brian Gene — Florida State University
- Study coordinator: Miller, Brian Gene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.