Understanding how proteins are modified with sugars in cells
Scramblases for protein glycosylation
This study is looking at how certain proteins get the sugars they need to work properly, which is important for everyone, including people with conditions like muscular dystrophy, and it aims to find out how specific helpers in our cells can improve our understanding and treatment of these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11046664 on NIH RePORTER |
What this research studies
This research investigates the process of protein glycosylation, which is crucial for the proper functioning of proteins in all eukaryotic organisms, including humans. The study focuses on identifying specific transporters, known as scramblases, that facilitate the movement of glycolipids necessary for glycosylation across the endoplasmic reticulum membrane. By using various assays, the research aims to uncover how these scramblases operate and their role in diseases linked to glycosylation defects, such as muscular dystrophy and certain congenital disorders. Patients may benefit from a better understanding of these processes, potentially leading to new therapeutic strategies for related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital disorders of glycosylation or related diseases that involve glycosylation defects.
Not a fit: Patients without any glycosylation-related disorders or those not affected by the diseases studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by defects in protein glycosylation.
How similar studies have performed: Other research has shown success in understanding glycosylation processes, indicating that this approach has potential for meaningful advancements.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Menon, Anant K — Weill Medical Coll of Cornell Univ
- Study coordinator: Menon, Anant K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.